inferior pharyngeal constrictor and cricopharngeus

INFERIOR PHARYNGEAL CONSTRICTOR AND CRICOPHARNGEUS TRIAL

The influence of delineation variability on dose delivered to the constrictor muscles with Do-IMRT and resultant normal tissue complication probability (NTCP) for physician-scored radiation-associated dysphagia at 6 months was evaluated. Methods and Materials: Outlining accuracy of 15 clinicians’ superior and middle PCM (SMPCM) and inferior PCM (IPCM) were retrospectively assessed against gold standards (GS) using volume, location, and conformity indices (CIs) on a pre-trial benchmark case of oropharyngeal cancer.

INFERIOR PHARYNGEAL CONSTRICTOR AND CRICOPHARNGEUS TRIAL

5Clinical Trials and Statistics Unit, Institute of Cancer Research, London, United Kingdomīackground and Purpose: To evaluate the inter-observer variation (IOV) in pharyngeal constrictor muscle (PCM) contouring, and resultant impact on dosimetry and estimated toxicity, as part of the pre-trial radiotherapy trial quality assurance (RTQA) within DARS, a multicenter phase III randomized controlled trial investigating the functional benefits of dysphagia-optimized intensity-modulated radiotherapy (Do-IMRT) in pharyngeal cancers.4Department of Physics, Royal Marsden NHS Foundation Trust, London, United Kingdom.3Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.2Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom.1Head and Neck Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom.Imran Petkar 1,2*† Dualta McQuaid 3 Alex Dunlop 3 Justine Tyler 4 Emma Hall 5 Chris Nutting 1,2

Inferior pharyngeal constrictor and cricopharngeus